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British anti-Lewisite (BAL; dimercaprol; 2,3-dimercaptopropanol) has been in use in the medical community for over 60 years. It is most commonly used as a. Dimercaprol is the drug of choice for treatment of acute arsenic, inorganic or elemental mercury, gold, and inorganic lead (in combination with EDTA) poisoning. The development of BAL must first start with its nemesis: Lewisite. Lewisite is a combination of acetylene and arsenic trichloride (figure 1) and has also been.

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Improvements in synthesis resulted in the development of effective therapeutic ointments and solutions. Plans for the possible production ofpounds per year were developed Waters and Stock If you are a subscriber, please log in.

Dimercaprol was first made during World War II. Dimercaprol has long been the mainstay of chelation therapy for lead or arsenic poisoning, [8] and it remains an essential drug.

Archived from the original on The content you are trying to view is available only to logged in, current MedLink Neurology subscribers. Our editors will review what you’ve submitted, and if it meets our criteria, we’ll add znti to the article.

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Dimercaprol also enhances the toxicity of selenium and telluriumso it is not to be used to remove these elements from the body. Archived PDF from the original on 13 December Please try again later.

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Nevertheless, BAL may still have some therapeutic value in patients who do ant respond well to more modern agents Scheinberg and Sternlieb Wilson’s disease is a genetic disorder in which copper builds up inside the liver and other tissues. Any text you add should be original, not copied from other sources.


The Editors of Encyclopaedia Britannica. Lewisite 2-chlorovinyldichoroarsine is an arsenic-based vesicant chemical warfare agent that was initially developed, although not used, by the United States during World War I.

Contact our editors with your feedback. Help us improve this article! Arsenic and some other heavy metals act by chemically reacting with adjacent thiol residues on metabolic enzymes, creating a chelate complex that inhibits the affected enzyme’s activity.

You may find it helpful to search within the site to see how similar or related subjects are covered. At the bottom of the article, feel free to list any sources that support your changes, so that we can fully understand their context. The Royal Society of Chemistry. Other drawbacks include the need to administer it by painful intramuscular injection.

British anti-Lewisite :: Development

You can make it easier for us to review and, hopefully, publish your contribution by keeping a few points in mind. InPorter found a 7-fold increase in copper excretion in 2 patients with Wilson disease and some decrease in neurologic signs after treatment with BAL Porter It was believed to have much greater toxicity than mustard brotish, with some animal data suggesting that as little as one-third teaspoon on the skin would result in human death Vilensky Dimercaprol Edetates Prussian blue.

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If you prefer to suggest your own revision of the article, you can go to edit mode requires login. It was also considered effective in cases of intoxication with bismuth, copper, and nickel Deichmann and Gerarde It is a potentially toxic drug, and its use may be accompanied by multiple side effects.

Dimercaprol is more effective if its use is begun within two hours after ingestion of the toxic metal.

British anti-Lewisite :: Clinical Use

anri Originally released November 30, ; last updated April 23, ; expires April 23, Its original name reflects its origins qnti a compound secretly developed by British biochemists at Oxford University during World War II [13] [14] as an antidote for lewisitea now-obsolete arsenic -based chemical warfare agent.

Human and Experimental Toxicology Dimercaprolalso called British anti-Lewisite BALis a medication used to treat acute poisoning by arsenicmercurygoldand lead. Eagle and Magnuson found that 48 patients with severe or mild symptoms of pewisite encephalopathy were effectively treated with BAL Eagle and Magnuson Thank you for your feedback. If you are a former subscriber or have registered before, please log in first and then click select a Service Plan or contact Subscriber Services.

Dimercaprol has been found to form stable chelates in vivo with many other metals including inorganic mercuryantimonybismuthcadmiumchromiumcobaltgoldand lewixite. Artificial intelligence AIthe ability of a digital computer or computer-controlled robot to perform…. Learn More in these related Britannica articles: